Results showed childrenof mothers who smoked 10 or more cigarettes a day are on average 1.0 centimeters shorterand between three and five months behind in reading, mathematics, and general ability whencompared to the offspring of non-smokers, after allowing for associated social andbiological factors (see fig.1 & 2).
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We separated women who smoked from those who did not smoke during pregnancy and then analysed the association between rs1051730, and child birth weight. We observed that smoking status during pregnancy modifies the association between maternal rs1051730 genotype and offspring birth weight. Each additional copy of the risk allele in smokers resulted in a significant 20 gram reduction in birth weight. In contrast in non-smoking mothers no significant association between the rs1051730 variant and birth weight were observed. These results suggest that smoking during pregnancy causes lower birth weight babies.
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